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KMID : 1094720160210010175
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Biotechnology and Bioprocess Engineering
2016 Volume.21 No. 1 p.175 ~ p.182
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Hair growth effects of Laminaria japonica extract and growth factor mixture on a C57BL/6 mouse model
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Lee Bong-Moo
Park Ki-Soo
Lee Yong-Jig
Choi Eun-Som
Park Dae-Hwan
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Abstract
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To develop a drug to treat hair loss, we evaluated the effects of Laminaria japonica extract mixed with growth factor. After topical application of the L. japonica growth factor mixture to a six-week-old C57BL/6 mouse model, analysis of hair re-growth was determined using a high-resolution hair analysis system, as well as, photographic and histologic analysis. Depilated areas were completely covered with fully-grown hair in all study groups (control group, L. japonica extract group, and L. japonica extract mixed with growth factor group) and the hair re-growth score was the highest in the group treated with L. japonica supplemented with insulin-like growth factor-1 (IGF-1). The width and length of the hair follicles showed a significant increase in the groups treated with L. japonica mixed with IGF-1, compared to the control groups. Groups treated with L. japonica mixed with growth factor showed significantly increased gene expression of IGF-1 and decreased expression of transforming growth factor (TGF)-β, compared to the control groups. We confirmed that IGF-1 was more effective in promoting hair growth than vascular endothelial growth factor (VEGF). Therefore, we suggest that L. japonica mixed with IGF-1 could successfully be used to treat patients with alopecia; however, clinical trials and additional studies on the side effects of the mixture are necessary.
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KEYWORD
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alopecia, Laminaria japonica, growth factor, IGF-1, anti-hair loss, hair growth
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